Article
Interferon-α induces marked alterations in circulating regulatory T cells, NK cell subsets, and dendritic cells in patients with JAK2V617F-positive essential thrombocythemia and polycythemia vera.
European journal of haematology - 1 Jul 2016
Riley Caroline H, Brimnes Marie K, Hansen Morten, Jensen Morten Krogh, Hasselbalch Hans C, Kjaer Lasse, Straten Per Thor, Svane Inge Marie
Abstract excerpt
Long-term therapy with IFN-α2 is associated with sustained major molecular remissions in JAK2-positive ET and PV. The efficacy of IFN-α2 may be partly mediated by modulation of immune cells, which was investigated in twenty patients with ET (n = 6) and PV (n = 14). The frequency of CD4(+) CD25(+) Foxp3(+) T cells was significantly increased during IFN-α2 treatment in all patients (P < 0.0001). A significant...
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