Article
Mipu1 inhibits lipid accumulation through down-regulation of CD36 in RAW264.7 cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2015
Qu Shun-Lin, Fan Wen-Jing, Zhang Chi, Guo Fang, Pan Wen-Jun, Han Dan, Li Wei, Zhu Yu-Ning, Jiang Zhi-Sheng
Abstract excerpt
BACKGROUND/AIMS: Our recent data indicated that Mipu1 overexpression reduces lipid intake and CD36 expression of macrophages in the presence of oxLDL. However, the mechanism of Mipu1 inhibiting lipid accumulation in macrophages is not elucidated. METHODS: Real-time quantitative polymerase chain reaction (PCR) and western blot analysis were used to detect expression of Mipu1 and CD36. The promoter activity of CD36...
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