Article
A mitochondrial DNA mutation influences the apoptotic effect of statins on prostate cancer.
The Prostate - 1 Dec 2015
Sun Qian, Arnold Rebecca S, Sun Carrie Q, Petros John A
Abstract excerpt
BACKGROUND: Statins, 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are currently the most widely used cholesterol-lowering drugs. Previous epidemiological studies have suggested that there may be be an association between statin use and decreased risk of prostate cancer progression. Both inherited and somatic mutations of the mitochondrial genome are linked to prostate cancer. The purpose...
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