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Article

MTHFR-Ala222Val and male infertility: a study in Iranian men, an updated meta-analysis and an in silico-analysis.

Reproductive biomedicine online - 1 Nov 2015

Nikzad Hossein, Karimian Mohammad, Sareban Kobra, Khoshsokhan Maryam, Hosseinzadeh Colagar Abasalt

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) functions as a main regulatory enzyme in folate metabolism. The association of MTHFR gene Ala222Val polymorphism with male infertility in an Iranian population was investigated by undertaking a meta-analysis and in-silico approach. A genetic association study included 497 men; 242 had unexplained infertility and 255 were healthy controls. Polymerase chain reaction...

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Source

Identifiers

PMID: 26380869
DOI: 10.1016/j.rbmo.2015.07.015

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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