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Article

Strong association of 677 C>T substitution in the MTHFR gene with male infertility--a study on an indian population and a meta-analysis.

PloS one - 1 Jan 2011

Gupta Nishi, Gupta Saraswati, Dama Madhukar, David Archana, Khanna Geeta, Khanna Anil, Rajender Singh

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, making it crucial for DNA synthesis and methylation. The objective of this study was to analyze MTHFR gene 677C>T polymorphism in infertile male individuals from North India, followed by a meta-analysis on our data and published studies. METHODOLOGY/PRINCIPAL FINDINGS: We undertook genotyping on a...

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Source

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Identifiers

PMID: 21799811
DOI: 10.1371/journal.pone.0022277
PMCID: PMC3140509

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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