Article
Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age.
Oncotarget - 13 Oct 2015
Fontebasso Adam M, Shirinian Margret, Khuong-Quang Dong-Anh, Bechet Denise, Gayden Tenzin, Kool Marcel, De Jay Nicolas, Jacob Karine, Gerges Noha, Hutter Barbara, Şeker-Cin Huriye, Witt Hendrik, Montpetit Alexandre, Brunet Sébastien, Lepage Pierre, Bourret Geneviève, Klekner Almos, Bognár László, Hauser Peter, Garami Miklós, Farmer Jean-Pierre, Montes Jose-Luis, Atkinson Jeffrey, Lambert Sally, Kwan Tony, Korshunov Andrey, Tabori Uri, Collins V Peter, Albrecht Steffen, Faury Damien, Pfister Stefan M, Paulus Werner, Hasselblatt Martin, Jones David T W, Jabado Nada
Abstract excerpt
Pilocytic astrocytoma (PA) is the most common brain tumor in children but is rare in adults, and hence poorly studied in this age group. We investigated 222 PA and report increased aneuploidy in older patients. Aneuploid genomes were identified in 45% of adult compared with 17% of pediatric PA. Gains were non-random, favoring chromosomes 5, 7, 6 and 11 in order of frequency, and preferentially affecting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.