Article

Heterogeneity of Insulin Resistance Surrogates in Thousands of Non-Diabetic Adults: Multi-Modal Data Reveals Discordant Metabolic Phenotypes

2026-05-04

Abstract excerpt

The transition from metabolic health to type 2 diabetes unfolds through progressive insulin resistance (IR), yet the gold-standard hyperinsulinemic-euglycemic clamp is inapplicable at population scale and fasting insulin is not uniformly available. Several surrogate measures have been described in the literature, but whether these surrogates identify the same individuals, and whether continuous glucose monitoring...

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Literature Corpus work: 4791343b-a898-546b-abd3-abc47d549d08
DOI: 10.64898/2026.05.02.26352290

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