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Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial.

Cell metabolism - 3 Jan 2023

Trouwborst Inez, Gijbels Anouk, Jardon Kelly M, Siebelink Els, Hul Gabby B, Wanders Lisa, Erdos Balázs, Péter Szabolcs, Singh-Povel Cécile M, de Vogel-van den Bosch Johan, Adriaens Michiel E, Arts Ilja C W, Thijssen Dick H J, Feskens Edith J M, Goossens Gijs H, Afman Lydia A, Blaak Ellen E

Abstract excerpt

Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. Women and men with MIR or LIR (n = 242, body mass index [BMI] 25-40 kg/m2, 40-75 years) were...

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Identifiers

PMID: 36599304
DOI: 10.1016/j.cmet.2022.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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