Article
A methodology for exploring biomarker--phenotype associations: application to flow cytometry data and systemic sclerosis clinical manifestations.
BMC bioinformatics - 15 Sept 2015
Huang Hongtai, Fava Andrea, Guhr Tara, Cimbro Raffaello, Rosen Antony, Boin Francesco, Ellis Hugh
Abstract excerpt
BACKGROUND: This work seeks to develop a methodology for identifying reliable biomarkers of disease activity, progression and outcome through the identification of significant associations between high-throughput flow cytometry (FC) data and interstitial lung disease (ILD) - a systemic sclerosis (SSc, or scleroderma) clinical phenotype which is the leading cause of morbidity and mortality in SSc. A specific aim...
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