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Article

Age-specific onset and distribution of the natural anticoagulant deficiency in pediatric thromboembolism.

Pediatric research - 1 Jan 2016

Ichiyama Masako, Ohga Shouichi, Ochiai Masayuki, Tanaka Koichi, Matsunaga Yuka, Kusuda Takeshi, Inoue Hirosuke, Ishimura Masataka, Takimoto Tomohito, Koga Yui, Hotta Taeko, Kang Dongchon, Hara Toshiro

Abstract excerpt

BACKGROUND: The early diagnosis of inherited thrombophilia in children is challenging because of the rarity and hemostatic maturation. METHODS: We explored protein C (PC), protein S (PS), and antithrombin (AT) deficiencies in 306 thromboembolic patients aged ≤20 y using the screening of plasma activity and genetic analysis. RESULTS: Reduced activities were determined in 122 patients (40%). Low PC patients were...

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Identifiers

PMID: 26372516
DOI: 10.1038/pr.2015.180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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