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Protein C deficiency as the major cause of thrombophilias in childhood

25 Mar 2013

Abstract excerpt

Genetic predisposition of thromboembolism depends on the racial background. Factor V Leiden (G1691A) and factor II mutation (G20210A) are the leading causes of inherited thrombophilias in Caucasians, but are not found in Asian ancestries. Protein S (PS), protein C (PC) and antithrombin (AT) activity are reportedly low in 65% of adult Japanese patients with deep vein thrombosis. Approximately half of the patients...

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PMID: 23521084
DOI: 10.1111/ped.12102

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