Article
Anticoagulant proteins in childhood venous and arterial thrombosis: a review.
Blood cells, molecules & diseases - 1 Oct 2000
Segel G B, Francis C A
Abstract excerpt
Thrombotic disease is less frequent in children than in adults, but may result in severe morbidity and mortality. The coagulation system is balanced to provide rapid activation to stop bleeding and appropriate inhibition to prevent unwanted clot extension. It is regulated by fibrinolysis and by three major anticoagulant pathways: the protein C, antithrombin, and tissue factor pathway inhibitor systems. Acquired...
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