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Article

Modeling the energetic cost of cancer as a result of altered energy metabolism: implications for cachexia

15 Sept 2015

Abstract excerpt

BACKGROUND: Cachexia affects most patients with incurable cancer. We hypothesize that in metastatic cancer the mass of the tumor as well as its level of anaerobic energy metabolism play a critical role in describing its energetic cost, which results in elevated resting energy expenditure and glucose utilization, leading to cachexia. Prior models of cancer cachexia may have underestimated the specific energetic...

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PMID: 26370269
DOI: 10.1186/s12976-015-0015-0

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