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Article

Self-assembly is prerequisite for catalysis of Fe(II) oxidation by catalytically active subunits of ferritin.

The Journal of biological chemistry - 30 Oct 2015

Ebrahimi Kourosh Honarmand, Hagedoorn Peter-Leon, Hagen Wilfred R

Abstract excerpt

Fe(III) storage by ferritin is an essential process of the iron homeostasis machinery. It begins by translocation of Fe(II) from outside the hollow spherical shape structure of the protein, which is formed as the result of self-assembly of 24 subunits, to a di-iron binding site, the ferroxidase center, buried in the middle of each active subunit. The pathway of Fe(II) to the ferroxidase center has remained...

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Identifiers

PMID: 26370076
DOI: 10.1074/jbc.M115.678375
PMCID: PMC4646333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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