Article
Directing noble metal ion chemistry within a designed ferritin protein.
Biochemistry - 2 Dec 2008
Butts Christopher A, Swift Joe, Kang Seung-Gu, Di Costanzo Luigi, Christianson David W, Saven Jeffery G, Dmochowski Ivan J
Abstract excerpt
Human H ferritin (HuHF) assembles from 24 four-helix bundles to form an approximately 500 kDa protein with an 8 nm internal cavity. HuHF provides a useful model for studying the transport of metal ions in solution to buried reaction sites in proteins. In this study, HuHF was redesigned to facilitate noble metal ion (Au(3+), Ag(+)) binding, reduction, and nanoparticle formation within the cavity. Computationally...
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