Article
Emergence of Amoxicillin-Resistant Variants of Spain9V-ST156 Pneumococci Expressing Serotype 11A Correlates with Their Ability to Evade the Host Immune Response.
PloS one - 1 Jan 2015
Aguinagalde Leire, Corsini Bruno, Domenech Arnau, Domenech Mirian, Cámara Jordi, Ardanuy Carmen, García Ernesto, Liñares Josefina, Fenoll Asunción, Yuste Jose
Abstract excerpt
Capsular switching allows pre-existing clones of Streptococcus pneumoniae expressing vaccine serotypes to escape the vaccine-induced immunity by acquisition of capsular genes from pneumococci of a non-vaccine serotype. Here, we have analysed the clonal composition of 492 clinical isolates of serotype 11A causing invasive disease in Spain (2000-2012), and their ability to evade the host immune response....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.