Article
Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in Turkish patients with ankylosing spondylitis.
The clinical respiratory journal - 1 Sept 2017
Karakose Okyaltırık Fatmanur, Rezvani Aylin, Turan Saime, Uysal Ömer, Yakar Fatih, Sozgen Hatice, Ozkan Nazlı Ezgi, Akkoyunlu Muhammet Emin, Bayram Mehmet, Kutbay Ozcelik Hatice, Sezer Murat, Guler Mustafa, Yaylım İlhan, Kart Levent
Abstract excerpt
BACKGROUND AND AIMS: Ankylosing spondylitis (AS) is a multisystem disorder with ocular, pulmonary, and cardiovascular involvement. The incidence of pulmonary involvement varies from 1 to 52%. Abnormal T-cell function-derived immune responses are involved in AS pathogenesis. Numerous genes such as CTLA4 and CD28 control T-cell functions. In this study, we aimed to address the relationship between CTLA4 and CD28...
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