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Article

Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L.

Human molecular genetics - 15 Nov 2015

Zhou Jian, Stein Paula, Leu N Adrian, Chmátal Lukáš, Xue Jiangyang, Ma Jun, Huang Xiaoyan, Lampson Michael A, Schultz Richard M, Wang P Jeremy

Abstract excerpt

Menopause results from loss of ovarian function and marks the end of a woman's reproductive life. Alleles of the human SYCP2L locus are associated with age at natural menopause (ANM). SYCP2L is a paralogue of the synaptonemal complex protein SYCP2 and is expressed exclusively in oocytes. Here we report that SYCP2L localizes to centromeres of dictyate stage oocytes, which represent the limited pool of primordial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26362258
DOI: 10.1093/hmg/ddv359
PMCID: PMC4614708

Genes

SYCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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