Article
Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis.
Aging cell - 1 Aug 2004
Csoka Antonei B, English Sangeeta B, Simkevich Carl P, Ginzinger David G, Butte Atul J, Schatten Gerald P, Rothman Frank G, Sedivy John M
Abstract excerpt
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease with widespread phenotypic features resembling premature aging. HGPS was recently shown to be caused by dominant mutations in the LMNA gene, resulting in the in-frame deletion of 50 amino acids near the carboxyl terminus of the encoded lamin A protein. Children with this disease typically succumb to myocardial infarction or stroke caused by...
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