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Article

TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast.

British journal of cancer - 20 Oct 2015

Yoshida Masayuki, Ogawa Reiko, Yoshida Hiroshi, Maeshima Akiko, Kanai Yae, Kinoshita Takayuki, Hiraoka Nobuyoshi, Sekine Shigeki

Abstract excerpt

BACKGROUND: Phyllodes tumors are rare fibroepithelial neoplasms of the breast, which carry the potential risk of local recurrence and metastasis. Phyllodes tumors share several histological features with fibroadenomas, and no widely accepted markers for distinguishing these lesions have been identified. METHODS: We analyzed molecular abnormalities related to telomere elongation in tumors, including TERT promoter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26355235
DOI: 10.1038/bjc.2015.326
PMCID: PMC4647876

Genes

TERT
MED12
ATRX
DAXX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast.PMID 26355235Read ↗

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Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathwaysSemantic proximity Read ↗

MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours.Semantic proximity Read ↗

Genetic and Clinical Characteristics of Phyllodes Tumors of the BreastSemantic proximity Read ↗

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression.Semantic proximity Read ↗

MED12, TERT and RARA in fibroepithelial tumours of the breast.Semantic proximity Read ↗

MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways.Semantic proximity Read ↗

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MED12 exon 2 and TERT promoter mutations in primary and recurrent breast fibroepithelial lesions.Semantic proximity Read ↗

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