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Article

Impaired osteogenesis in Menkes disease-derived induced pluripotent stem cells.

Stem cell research & therapy - 7 Sept 2015

Kim Dongkyu, Choi Jieun, Han Kyu-Min, Lee Beom Hee, Choi Jin-Ho, Yoo Han-Wook, Han Yong-Mahn

Abstract excerpt

INTRODUCTION: Bone abnormalities, one of the primary manifestations of Menkes disease (MD), include a weakened bone matrix and low mineral density. However, the molecular and cellular mechanisms underlying these bone defects are poorly understood. METHODS: We present in vitro modeling for impaired osteogenesis in MD using human induced pluripotent stem cells (iPSCs) with a mutated ATP7A gene. MD-iPSC lines were...

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Identifiers

PMID: 26347346
DOI: 10.1186/s13287-015-0147-5
PMCID: PMC4562349

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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