Article
A new in vitro model to delay high phosphate-induced vascular calcification progression.
Molecular and cellular biochemistry - 1 Dec 2015
Ciceri Paola, Elli Francesca, Cappelletti Laura, Tosi Delfina, Braidotti Paola, Bulfamante Gaetano, Cozzolino Mario
Abstract excerpt
An increasing amount of patients affected by advanced chronic kidney disease suffer from vascular calcification (VC) that associates with cardiovascular morbidity and mortality. In this study, we created a new experimental in vitro model, trying to better elucidate high phosphate (Pi)-induced VC pathogenic mechanisms. Rat aortic vascular smooth muscle cells (VSMCs) were challenged for 7-10 days with high Pi with...
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