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Article

Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.

Blood - 15 Mar 2006

Hassenpflug Wolf Achim, Budde Ulrich, Obser Tobias, Angerhaus Dorothea, Drewke Elke, Schneppenheim Sonja, Schneppenheim Reinhard

Abstract excerpt

Classical von Willebrand disease (VWD) type 2A, the most common qualitative defect of VWD, is caused by loss of high-molecular-weight multimers (HMWMs) of von Willebrand factor (VWF). Underlying mutations cluster in the A2 domain of VWF around its cleavage site for ADAMTS13. We investigated the impact of mutations commonly found in patients with VWD type 2A on ADAMTS13-dependent proteolysis of VWF. We used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16322474
DOI: 10.1182/blood-2005-04-1758

Genes

VWF
ADAMTS13

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.PMID 16322474Read ↗

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