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Article

[Increased susceptibility of recombinant type 2A von Willebrand factor mutant A1500E to proteolysis by ADAMTS13].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Mar 2012

Zhang Jing-yu, Su Jian, Ma Zhen-ni, Dong Ning-zheng, Wang Ying-chun, Ruan Chang-geng

Abstract excerpt

OBJECTIVE: To investigate the susceptibility of von Willebrand factor (VWF) type 2A mutant A1500E to proteolysis by metalloprotease ADAMTS13 and to provide the direct supports for the pathogenesis of VWF mutation A1500E responsible for von Willebrand disease (VWD) type 2A. METHODS: Recombinant wild-type VWF (WT-VWF) and A1500E mutant VWF transiently expressed on transfected HeLa cell lines. Expression media were...

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Identifiers

PMID: 22781599

Genes

VWF
ADAMTS13
SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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