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Article

Effect of von Willebrand disease type 2B and type 2M mutations on the susceptibility of von Willebrand factor to ADAMTS-13.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2007

Rayes J, Hommais A, Legendre P, Tout H, Veyradier A, Obert B, Ribba A S, Girma J P

Abstract excerpt

BACKGROUND: von Willebrand disease (VWD) type 2 is associated with mutations in von Willebrand factor (VWF) that affect its secretion, multimeric pattern, affinity for platelet receptors and clearance of the protein. While increased proteolysis by a disintegrin-like and metalloprotease with thrombospondin type 1 motifs-13 (ADAMTS-13) has been clearly established for VWF type 2A, only little is known about VWF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17087728
DOI: 10.1111/j.1538-7836.2007.02296.x

Genes

VWF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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Effect of von Willebrand disease type 2B and type 2M mutations on the susceptibility of von Willebrand factor to ADAMTS-13.PMID 17087728Read ↗

The co-influence of VWD type 2B/2M mutations in the A1 domain and platelet GPIbα on the rate of cleavage to VWF by ADAMTS13.Semantic proximity Read ↗

Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.Semantic proximity Read ↗

[Increased susceptibility of recombinant type 2A von Willebrand factor mutant A1500E to proteolysis by ADAMTS13].Semantic proximity Read ↗

A common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct.Semantic proximity Read ↗

A cluster of mutations in the D3 domain of von Willebrand factor correlates with a distinct subgroup of von Willebrand disease: type 2A/IIE.Semantic proximity Read ↗

ADAMTS13 cleavage efficiency is altered by mutagenic and, to a lesser extent, polymorphic sequence changes in the A1 and A2 domains of von Willebrand factor.Semantic proximity Read ↗

Clinical and laboratory phenotype variability in type 2M von Willebrand disease.Semantic proximity Read ↗

Structural and functional correlation of ADAMTS13.Semantic proximity Read ↗

Type 2M/2A von Willebrand disease: a shared phenotype between type 2M and 2A.Semantic proximity Read ↗

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