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Article

Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes From a Subset of Patients With Familial Colorectal Carcinomas.

Gastroenterology - 1 Dec 2015

Arora Sanjeevani, Yan Hong, Cho Iltaeg, Fan Hua-Ying, Luo Biao, Gai Xiaowu, Bodian Dale L, Vockley Joseph G, Zhou Yan, Handorf Elizabeth A, Egleston Brian L, Andrake Mark D, Nicolas Emmanuelle, Serebriiskii Ilya G, Yen Timothy J, Hall Michael J, Golemis Erica A, Enders Greg H

Abstract excerpt

BACKGROUND & AIMS: DNA structural lesions are prevalent in sporadic colorectal cancer. Therefore, we proposed that gene variants that predispose to DNA double-strand breaks (DSBs) would be found in patients with familial colorectal carcinomas of an undefined genetic basis (UFCRC). METHODS: We collected primary T cells from 25 patients with UFCRC and matched patients without colorectal cancer (controls) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26344056
DOI: 10.1053/j.gastro.2015.08.052
PMCID: PMC4663158

Genes

ERCC6
WRN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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