Article
The nonstructural protein 11 of porcine reproductive and respiratory syndrome virus inhibits NF-κB signaling by means of its deubiquitinating activity.
Molecular immunology - 1 Dec 2015
Wang Dang, Fan Jinxiu, Fang Liurong, Luo Rui, Ouyang Haiping, Ouyang Chao, Zhang Huan, Chen Huanchun, Li Kui, Xiao Shaobo
Abstract excerpt
Since its emergence in the late 1980s, porcine reproductive and respiratory syndrome (PRRS) has been devastating the swine industry worldwide. The causative agent is an Arterivirus, referred to as PRRS virus (PRRSV). The pathogenic mechanisms of PRRS are poorly understood, but are believed to correlate with the ability of PRRSV to inhibit immune responses of the host. However, precisely how the virus is capable...
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