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Article

Adaptive mutations at lysine residues of PRRSV-2 nsp12 enable evasion of host proteasomal degradation to promote subgenomic RNA synthesis.

Journal of virology - 21 Jul 2026

Chen Yongjie, Chen Zishen, Huang Ling, Zeng Siyong, Huang Baoying, Guo Chunhe

Abstract excerpt

Ubiquitin signaling in viral infections can either enhance immune responses and degrade viral proteins or be exploited by viruses to target host antiviral factors. Porcine reproductive and respiratory syndrome virus (PRRSV) poses a threat to the swine industry, with its non-structural proteins (nsps) critical for virulence and replication. Here, we investigated the role of ubiquitination in regulating the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42267824
DOI: 10.1128/jvi.00479-26
PMCID: PMC13386911

Genes

RNF114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Adaptive mutations at lysine residues of PRRSV-2 nsp12 enable evasion of host proteasomal degradation to promote subgenomic RNA synthesis.PMID 42267824Read ↗

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