Article

Adaptive mutations at lysine residues of PRRSV nsp12 enable evasion of host proteasomal and selective autophagic degradation

2025-09-02

Abstract excerpt

Ubiquitin signaling in viral infections can either enhance immune responses and degrade viral proteins or be exploited by viruses to target host antiviral factors. Porcine reproductive and respiratory syndrome virus (PRRSV) poses a significant threat to the pig industry, with its non-structural proteins (nsps) critical for virulence and replication. Here, we investigated the role of ubiquitination in the stability...

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Literature Corpus work: 5f83266a-6d34-5e93-b593-64415e22e039
DOI: 10.1101/2025.09.02.673672

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