Gene-by-social-environment interaction (GxSE) between ADCYAP1R1 genotype and neighborhood crime predicts major depression symptoms in trauma-exposed women.

doi:10.1016/j.jad.2015.08.002

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Article

Gene-by-social-environment interaction (GxSE) between ADCYAP1R1 genotype and neighborhood crime predicts major depression symptoms in trauma-exposed women.

Journal of affective disorders - 15 Nov 2015

Lowe Sarah R, Pothen John, Quinn James W, Rundle Andrew, Bradley Bekh, Galea Sandro, Ressler Kerry J, Koenen Karestan C

Abstract excerpt

BACKGROUND: Few studies have explored interactions between genes and social environmental exposures (GxSEs) for trauma-related psychopathology, including symptoms of posttraumatic stress (PTS) and major depression (MD). The extant literature suggests the possibility of a GxSE between the rs2267735 variant of the ADCYAP1R1 gene and neighborhood crime. The current study aimed to explore this possibility among a...

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PMID: 26334183
DOI: 10.1016/j.jad.2015.08.002
PMCID: PMC4587299

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