GENOME-WIDE ASSOCIATION STUDY (GWAS) AND GENOME-WIDE BY ENVIRONMENT INTERACTION STUDY (GWEIS) OF DEPRESSIVE SYMPTOMS IN AFRICAN AMERICAN AND HISPANIC/LATINA WOMEN.

doi:10.1002/da.22484

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GENOME-WIDE ASSOCIATION STUDY (GWAS) AND GENOME-WIDE BY ENVIRONMENT INTERACTION STUDY (GWEIS) OF DEPRESSIVE SYMPTOMS IN AFRICAN AMERICAN AND HISPANIC/LATINA WOMEN.

Depression and anxiety - 1 Apr 2016

Dunn Erin C, Wiste Anna, Radmanesh Farid, Almli Lynn M, Gogarten Stephanie M, Sofer Tamar, Faul Jessica D, Kardia Sharon L R, Smith Jennifer A, Weir David R, Zhao Wei, Soare Thomas W, Mirza Saira S, Hek Karin, Tiemeier Henning, Goveas Joseph S, Sarto Gloria E, Snively Beverly M, Cornelis Marilyn, Koenen Karestan C, Kraft Peter, Purcell Shaun, Ressler Kerry J, Rosand Jonathan, Wassertheil-Smoller Sylvia, Smoller Jordan W

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have made little progress in identifying variants linked to depression. We hypothesized that examining depressive symptoms and considering gene-environment interaction (GxE) might improve efficiency for gene discovery. We therefore conducted a GWAS and genome-wide by environment interaction study (GWEIS) of depressive symptoms. METHODS: Using data from the SHARe...

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PMID: 27038408
DOI: 10.1002/da.22484
PMCID: PMC4826276

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