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Article

Adversity in childhood and depression: linked through SIRT1

1 Sept 2015

Abstract excerpt

Experiencing an adverse childhood and parental neglect is a risk factor for depression in the adult population. Patients with a history of traumatic childhood develop a subtype of depression that is characterized by earlier onset, poor treatment response and more severe symptoms. The long-lasting molecular mechanisms that are engaged during early traumatic events and determine the risk for depression are poorly...

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PMID: 26327687
DOI: 10.1038/tp.2015.125

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