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Article

Nonhuman primate models of depression: effects of early experience and stress.

ILAR journal - 1 Jan 2014

Worlein Julie M

Abstract excerpt

Depression causes significant morbidity in the human population. The Diathesis-Stress/Two-Hit model of depression hypothesizes that stress interacts with underlying (probably genetic) predispositions to produce a central nervous system that is primed to express psychopathology when confronted with stressful experiences later in life. Nonhuman primate (NHP) studies have been extensively utilized to test this...

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Identifiers

PMID: 25225305
DOI: 10.1093/ilar/ilu030
PMCID: PMC4240441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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