Article
CD21 and CD19 deficiency: Two defects in the same complex leading to different disease modalities.
Clinical immunology (Orlando, Fla.) - 1 Dec 2015
Wentink Marjolein W J, Lambeck Annechien J A, van Zelm Menno C, Simons Erik, van Dongen Jacques J M, IJspeert Hanna, Schölvinck Elisabeth H, van der Burg Mirjam
Abstract excerpt
PURPOSE: Deficiencies in CD19 and CD81 (forming the CD19-complex with CD21 and CD225) cause a severe clinical phenotype. One CD21 deficient patient has been described. We present a second CD21 deficient patient, with a mild clinical phenotype and compared the immunobiological characteristics of CD21 and CD19 deficiency. METHODS: CD21 deficiency was characterized by flowcytometric immunophenotyping and sequencing....
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