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NDRG1 and its family members: More than just metastasis suppressor proteins and targets of thiosemicarbazones

14 May 2025

Abstract excerpt

N-Myc downstream regulated gene-1 (NDRG1) and the other three members of this family (NDRG2, 3, and 4) play various functional roles in the cellular stress response, differentiation, migration, and development. These proteins are involved in regulating key signaling proteins and pathways that are often dysregulated in cancer, such as EGFR, PI3K/AKT, c-Met, and the Wnt pathway. NDRG1 is the primary, well-examined...

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PMID: 40378957
DOI: 10.1016/j.jbc.2025.110230

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