Article
Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations.
The Journal of molecular diagnostics : JMD - 1 Sept 2015
Damodaran Senthilkumar, Miya Jharna, Kautto Esko, Zhu Eliot, Samorodnitsky Eric, Datta Jharna, Reeser Julie W, Roychowdhury Sameek
Abstract excerpt
Massively parallel sequencing technologies have enabled characterization of genomic alterations across multiple tumor types. Efforts have focused on identifying driver mutations because they represent potential targets for therapy. However, because of the presence of driver and passenger mutations, it is often challenging to assign the clinical relevance of specific mutations observed in patients. Currently,...
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