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Article

TGFβ signaling is required for sprouting lymphangiogenesis during lymphatic network development in the skin.

Development (Cambridge, England) - 1 Sept 2013

James Jennifer M, Nalbandian Ani, Mukouyama Yoh-suke

Abstract excerpt

Dermal lymphatic endothelial cells (LECs) emerge from the dorsolateral region of the cardinal veins within the anterior trunk to form an intricate, branched network of lymphatic vessels during embryogenesis. Multiple growth factors and receptors are required for specification and maintenance of LECs, but the mechanisms coordinating LEC movements and morphogenesis to develop three-dimensional lymphatic network...

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Share to Cell Shape
Share to Embryo, Mammalian
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphangiogenesis

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Share to Receptors, Transforming Growth Factor beta

Share to Vascular Endothelial Growth Factor Receptor-3

Source

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Identifiers

PMID: 23946447
DOI: 10.1242/dev.095026
PMCID: PMC3754483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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