Article
Review of the function of SEMA3A in lymphatic vessel maturation and its potential as a candidate gene for lymphedema: Analysis of three families with rare causative variants.
Lymphology - 1 Jan 2020
Ricci M, Daolio C, Amato B, Kenanoglu S, Veselenyiova D, Kurti D, Dautaj A, Baglivo M, Basha S H, Priya S, Serrani R, Dundar M, Krajcovic J, Bertelli M
Abstract excerpt
SEMA3A is a semaphorin involved in cell signaling with PlexinA1 and Neuropilin-1 (NRP1) receptors and it is responsible for recruiting dendritic cells into lymphatics. Mutations in the SEMA3A gene result in abnormalities in lymphatic vessel development and maturation. We investigated the association of SEMA3A variants detected in lymphedema patients with lymphatic maturation and lymphatic system malfunction....
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