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Article

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.

Circulation research - 3 Aug 2012

Bouvrée Karine, Brunet Isabelle, Del Toro Raquel, Gordon Emma, Prahst Claudia, Cristofaro Brunella, Mathivet Thomas, Xu Yunling, Soueid Jihane, Fortuna Vitor, Miura Nayoki, Aigrot Marie-Stéphane, Maden Charlotte H, Ruhrberg Christiana, Thomas Jean Léon, Eichmann Anne

Abstract excerpt

RATIONALE: The lymphatic vasculature plays a major role in fluid homeostasis, absorption of dietary lipids, and immune surveillance. Fluid transport depends on the presence of intraluminal valves within lymphatic collectors. Defective formation of lymphatic valves leads to lymphedema, a progressive and debilitating condition for which curative treatments are currently unavailable. How lymphatic valve formation is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22723296
DOI: 10.1161/CIRCRESAHA.112.269316
PMCID: PMC3861899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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