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Article

Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances.

The Journal of biological chemistry - 21 Nov 2014

Krishnan Shuba, Paredes João A, Zhou Xiaoshan, Kuiper Raoul V, Hultenby Kjell, Curbo Sophie, Karlsson Anna

Abstract excerpt

Mitochondrial DNA depletion caused by thymidine kinase 2 (TK2) deficiency can be compensated by a nucleoside kinase from Drosophila melanogaster (Dm-dNK) in mice. We show that transgene expression of Dm-dNK in Tk2 knock-out (Tk2(-/-)) mice extended the life span of Tk2(-/-) mice from 3 weeks to a...

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Identifiers

PMID: 25296759
DOI: 10.1074/jbc.M114.588921
PMCID: PMC4239632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-25296759-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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