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Article

KRAS mutations in microsatellite instable gastric tumours: impact of targeted treatment and intratumoural heterogeneity.

Virchows Archiv : an international journal of pathology - 1 Oct 2015

Queirós Pedro, Pinheiro Hugo, Carvalho Joana, Oliveira Patrícia, Gullo Irene, Carneiro Fátima, Almeida Gabriela M, Oliveira Carla

Abstract excerpt

In gastric cancer (GC), epidermal growth factor receptor (EGFR) overexpression associates with poor prognosis. Addition of a chimeric monoclonal antibody against EGFR (cetuximab) to first-line treatment of metastatic colorectal tumours improved outcomes of patients (stratified for KRAS wild-type...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26318594
DOI: 10.1007/s00428-015-1823-7

Genes

KRAS
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26318594-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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KRAS mutations in microsatellite instable gastric tumours: impact of targeted treatment and intratumoural heterogeneity.PMID 26318594Read ↗

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