Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KRAS mutant allele-specific imbalance (MASI) assessment in routine samples of patients with metastatic colorectal cancer.

Journal of clinical pathology - 1 Apr 2015

Malapelle Umberto, Sgariglia Roberta, De Stefano Alfonso, Bellevicine Claudio, Vigliar Elena, de Biase Dario, Sepe Romina, Pallante Pierlorenzo, Carlomagno Chiara, Tallini Giovanni, Troncone Giancarlo

Abstract excerpt

AIMS: Patients with colorectal cancer harbouring KRAS mutations do not respond to antiepidermal growth factor receptor (anti-EGFR) therapy. Community screening for KRAS mutation selects patients for treatment. When a KRAS mutation is identified by direct sequencing, mutant and wild type alleles are seen on the sequencing electropherograms. KRAS mutant allele-specific imbalance (MASI) occurs when the mutant allele...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allelic Imbalance
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cetuximab

Share to Drug Screening Assays, Antitumor

Share to Laser Capture Microdissection

Share to Patient Selection

Share to Precision Medicine

Share to ras Proteins

Source

Identifiers

PMID: 25609577
DOI: 10.1136/jclinpath-2014-202761

Genes

KRAS
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KRAS mutant allele-specific imbalance (MASI) assessment in routine samples of patients with metastatic colorectal cancer.PMID 25609577Read ↗

Mutant allele-specific imbalance modulates prognostic impact of KRAS mutations in colorectal adenocarcinoma and is associated with worse overall survival.Semantic proximity Read ↗

Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights.Semantic proximity Read ↗

KRAS mutant allele-specific imbalance in lung adenocarcinoma.Semantic proximity Read ↗

Metastatic colorectal cancer KRAS genotyping in routine practice: results and pitfalls.Semantic proximity Read ↗

Comparison of KRAS mutation analysis of colorectal cancer samples by standard testing and next-generation sequencing.Semantic proximity Read ↗

Comprehensive Clinical and Molecular Characterization of KRAS G12C-Mutant Colorectal Cancer.Semantic proximity Read ↗

Oncogenic mutations and microsatellite instability phenotype predict specific anatomical subsite in colorectal cancer patients.Semantic proximity Read ↗

Prevalence of RAS mutations and individual variation patterns among patients with metastatic colorectal cancer: A pooled analysis of randomised controlled trials.Semantic proximity Read ↗

Heterogeneity of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer and potential effects on therapy in the CAPRI GOIM trial.Semantic proximity Read ↗

Tumor Heterogeneity Revealed byKRAS,BRAF, andPIK3CAPyrosequencing:KRASandPIK3CAIntratumor Mutation Profile Differences and Their Therapeutic ImplicationsSemantic proximity Read ↗

Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.Semantic proximity Read ↗

Mutant allele specific imbalance in oncogenes with copy number alterations: Occurrence, mechanisms, and potential clinical implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.