Article
Mutational analysis of ATP8B1 in patients with chronic pancreatitis.
PloS one - 1 Jan 2013
van der Woerd Wendy L, van Haaften-Visser Désirée Y, van de Graaf Stan F J, Férec Claude, Masson Emmanuelle, Stapelbroek Janneke M, Bugert Peter, Witt Heiko, Houwen Roderick H J
Abstract excerpt
BACKGROUND: Mutations in genes encoding cationic trypsinogen (PRSS1), pancreatic secretory trypsin inhibitor (SPINK1) and chymotrypsinogen C (CTRC) are associated with chronic pancreatitis. However, in many patients with a familial chronic pancreatitis pattern suggesting a genetic cause, no mutations in either of these genes can be found, indicating that other, still unknown, associated genes exist. In this...
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