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Article

Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2016

Zwart Sara R, Gregory Jesse F, Zeisel Steven H, Gibson Charles R, Mader Thomas H, Kinchen Jason M, Ueland Per M, Ploutz-Snyder Robert, Heer Martina A, Smith Scott M

Abstract excerpt

Ophthalmic changes have occurred in a subset of astronauts on International Space Station missions. Visual deterioration is considered the greatest human health risk of spaceflight. Affected astronauts exhibit higher concentrations of 1-carbon metabolites (e.g., homocysteine) before flight. We hy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26316272
DOI: 10.1096/fj.15-278457
PMCID: PMC4684521

Genes

MTRR
SHMT1
CBS
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26316272-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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