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Article

Evaluating vitamin C-related gene-environment and metabolite-environment interaction effects on intraocular pressure in the Canadian Longitudinal Study on Aging.

BMC genomic data - 29 Jan 2025

Lelievre Rebecca, Rakesh Mohan, Hysi Pirro G, Little Julian, Freeman Ellen E, Roy-Gagnon Marie-Hélène

Abstract excerpt

High intraocular pressure (IOP) is an important risk factor for glaucoma, which is influenced by genetic and environmental factors. However, the etiology of high IOP remains uncertain. Metabolites are compounds involved in metabolism which provide a link between the internal (genetic) and external environments. O-methylascorbate has been reported to be associated with IOP. In addition, researchers have identified...

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PMID: 39881263
DOI: 10.1186/s12863-025-01301-w
PMCID: PMC11776179

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