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Article

Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy.

Pharmacogenomics - 1 Jan 2015

Ma Chun-Lai, Jiao Zheng, Wu Xun-Yi, Hong Zhen, Wu Zhi-Yuan, Zhong Ming-Kang

Abstract excerpt

AIM: To evaluate the association between the major genetic variants involved in the pharmacokinetic/pharmacodynamic (PK/PD) properties of carbamazepine (CBZ) and its maintenance doses and concentrations. PATIENTS & METHODS: The genotypes of 166 patients receiving CBZ monotherapy were detected using high-resolution melting curve (HRM) and TaqMan methods. RESULTS: Both univariate and multiple regression analyses...

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Source

Identifiers

PMID: 26314341
DOI: 10.2217/pgs.15.94

Genes

EPHX1

Variants

Provenance

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