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Article

Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing.

Clinical neuropharmacology - 1 Jan 2000

Makmor-Bakry Mohd, Sills Graeme J, Hitiris Nikolas, Butler Elaine, Wilson Elaine A, Brodie Martin J

Abstract excerpt

OBJECTIVES: The dose of carbamazepine required to achieve optimal seizure control varies widely from patient to patient. We investigated polymorphic variants in various genes involved in the pharmacokinetics and pharmacodynamics of carbamazepine in an effort to identify predictors of maintenance dose. METHODS: : A total of 70 patients with epilepsy (49% were males; median age, 34 years; range, 14-72 years) who...

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Source

Identifiers

PMID: 19620853
DOI: 10.1097/WNF.0b013e318187972a

Genes

EPHX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing.PMID 19620853Read ↗

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