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Article

Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.

Journal of virology - 1 Nov 2015

Kell Alison, Stoddard Mark, Li Hui, Marcotrigiano Joe, Shaw George M, Gale Michael

Abstract excerpt

UNLABELLED: Despite the introduction of direct-acting antiviral (DAA) drugs against hepatitis C virus (HCV), infection remains a major public health concern because DAA therapeutics do not prevent reinfection and patients can still progress to chronic liver disease. Chronic HCV infection is supported by a variety of viral immune evasion strategies, but, remarkably, 20% to 30% of acute infections spontaneously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26311867
DOI: 10.1128/JVI.01964-15
PMCID: PMC4621103

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