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Article

The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7

27 Aug 2015

Abstract excerpt

Castration-resistant (CR) prostate cancer (PCa) partly arises due to persistence of androgen receptor (AR) transcriptional activity in the absence of cognate ligand. An emerging mechanism underlying the CRPCa phenotype and predicting response to therapy is the expression of the constitutively-active AR-V7 splice variant generated by AR cryptic exon 3b inclusion. Here, we explore the role of the RNA-binding...

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PMID: 26310125
DOI: 10.1038/srep13426

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