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Article

Identification of cellular mRNA targets for RNA-binding protein Sam68.

Nucleic acids research - 15 Dec 2002

Itoh Michiyasu, Haga Izumi, Li Qing-Hua, Fujisawa Jun-ichi

Abstract excerpt

Sam68 (Src-associated in mitosis, 68 kDa), a nuclear RNA-binding protein, has been postulated to play a role in cell-growth control as a modulator of signal transduction and activation of RNA metabolism. Although Sam68 was demonstrated to bind to the UAAA sequences in synthetic oligoribonucleotides and poly(U) homopolymers in vitro, the legitimate cellular mRNA target remained unclear. By using the differential...

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Identifiers

PMID: 12490714
DOI: 10.1093/nar/gkf673
PMCID: PMC140046

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